| First Author | Fukuhara K | Year | 2013 |
| Journal | Cell Rep | Volume | 5 |
| Issue | 3 | Pages | 748-58 |
| PubMed ID | 24210822 | Mgi Jnum | J:205528 |
| Mgi Id | MGI:5545706 | Doi | 10.1016/j.celrep.2013.10.005 |
| Citation | Fukuhara K, et al. (2013) Specificity of monosynaptic sensory-motor connections imposed by repellent Sema3E-PlexinD1 signaling. Cell Rep 5(3):748-58 |
| abstractText | In mammalian spinal cord, group Ia proprioceptive afferents form selective monosynaptic connections with a select group of motor pool targets. The extent to which sensory recognition of motor neurons contributes to the selectivity of sensory-motor connections remains unclear. We show here that proprioceptive sensory afferents that express PlexinD1 avoid forming monosynaptic connections with neurons in Sema3E(+) motor pools yet are able to form direct connections with neurons in Sema3E(off) motor pools. Anatomical and electrophysiological analysis of mice in which Sema3E-PlexinD1 signaling has been deregulated or inactivated genetically reveals that repellent signaling underlies aspects of the specificity of monosynaptic sensory-motor connectivity in these reflex arcs. A semaphorin-based system of motor neuron recognition and repulsion therefore contributes to the formation of specific sensory-motor connections in mammalian spinal cord. |
