| First Author | Rousso DL | Year | 2016 |
| Journal | Cell Rep | Volume | 15 |
| Issue | 9 | Pages | 1930-44 |
| PubMed ID | 27210758 | Mgi Jnum | J:235958 |
| Mgi Id | MGI:5804053 | Doi | 10.1016/j.celrep.2016.04.069 |
| Citation | Rousso DL, et al. (2016) Two Pairs of ON and OFF Retinal Ganglion Cells Are Defined by Intersectional Patterns of Transcription Factor Expression. Cell Rep 15(9):1930-44 |
| abstractText | Visual information is conveyed to the brain by axons of >30 retinal ganglion cell (RGC) types. Characterization of these types is a prerequisite to understanding visual perception. Here, we identify a family of RGCs that we call F-RGCs on the basis of expression of the transcription factor Foxp2. Intersectional expression of Foxp1 and Brn3 transcription factors divides F-RGCs into four types, comprising two pairs, each composed of closely related cells. One pair, F-mini(ON) and F-mini(OFF), shows robust direction selectivity. They are among the smallest RGCs in the mouse retina. The other pair, F-midi(ON) and F-midi(OFF), is larger and not direction selective. Together, F-RGCs comprise >20% of RGCs in the mouse retina, halving the number that remain to be classified and doubling the number of known direction-selective cells. Co-expression of Foxp and Brn3 genes also marks subsets of RGCs in macaques that could be primate homologs of F-RGCs. |
