| First Author | Yokota Y | Year | 2007 |
| Journal | PLoS One | Volume | 2 |
| Issue | 8 | Pages | e794 |
| PubMed ID | 17726524 | Mgi Jnum | J:129398 |
| Mgi Id | MGI:3769203 | Doi | 10.1371/journal.pone.0000794 |
| Citation | Yokota Y, et al. (2007) Radial glial dependent and independent dynamics of interneuronal migration in the developing cerebral cortex. PLoS One 2(8):e794 |
| abstractText | Interneurons originating from the ganglionic eminence migrate tangentially into the developing cerebral wall as they navigate to their distinct positions in the cerebral cortex. Compromised connectivity and differentiation of interneurons are thought to be an underlying cause in the emergence of neurodevelopmental disorders such as schizophrenia. Previously, it was suggested that tangential migration of interneurons occurs in a radial glia independent manner. Here, using simultaneous imaging of genetically defined populations of interneurons and radial glia, we demonstrate that dynamic interactions with radial glia can potentially influence the trajectory of interneuronal migration and thus the positioning of interneurons in cerebral cortex. Furthermore, there is extensive local interneuronal migration in tangential direction opposite to that of pallial orientation (i.e., in a medial to lateral direction from cortex to ganglionic eminence) all across the cerebral wall. This counter migration of interneurons may be essential to locally position interneurons once they invade the developing cerebral wall from the ganglionic eminence. Together, these observations suggest that interactions with radial glial scaffold and localized migration within the expanding cerebral wall may play essential roles in the guidance and placement of interneurons in the developing cerebral cortex. |
