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Protein Coding Gene : Parp2 poly (ADP-ribose) polymerase family, member 2
Primary Identifier  MGI:1341112 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  11546
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables NAD+ ADP-ribosyltransferase activity. Involved in decidualization. Acts upstream of or within base-excision repair and extrinsic apoptotic signaling pathway. Located in nucleolus and nucleoplasm. Is expressed in several structures, including central nervous system; gonad; liver; retina; and thymus. Orthologous to human PARP2 (poly(ADP-ribose) polymerase 2).
PHENOTYPE: Homozygous mutant animals are sensitive to gamma radiation. Epithelial crypt degeneration and DNA repair deficiency is apparent following radiation-induced injury. [provided by MGI curators]
  • synonyms:
  • Aspartl2,
  • EST C78626,
  • Parp2,
  • PARP-2,
  • C78626,
  • ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 2,
  • poly (ADP-ribose) polymerase family, member 2,
  • Adprt2,
  • ADP-ribosyltransferase (NAD+, poly(ADP-ribose) polymerase)-like 2,
  • Adprtl2,
  • MGI:1353643
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Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

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1 Involved In Mutations

Trail: ProteinCodingGene

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

13 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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