| Primary Identifier | MGI:96412 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 15925 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables endopeptidase activity. Involved in insulin catabolic process and insulin receptor recycling. Acts upstream of or within amyloid-beta clearance and response to oxidative stress. Located in extracellular exosome. Is active in endosome lumen. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human IDE (insulin degrading enzyme). PHENOTYPE: Mice homozygous for a null allele show beta amyloid accumulations in the brain, hyperinsulinemia, and glucose intolerance. Mice homozygous for a different null allele show decreased testis weight, small seminiferous tubules, abnormal sperm morphology, and decreased sperm viability. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
