| Primary Identifier | MGI:2388158 | Allele Type | Targeted |
| Gene | Scn5a | Transmission | Germline |
| Strain of Origin | Not Specified | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Sequence encoding lyusine-proline-glutamine (residues 1505-1507) were replaced by a single loxP site via homologous recombination followed by in vitro cre mediated excision. This deletion was designed to emulate long-QT3 (LQT3) syndrome, which results in the prolongation of the electrocardiographic QT interval. Quantitative RT-PCR and Western blot analysis confirmed that both transcript and protein levels produced by the targeted allele were comparable to wild-type expression. |
