| Primary Identifier | MGI:2154952 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 56532 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables protein serine/threonine kinase activity. Involved in several processes, including execution phase of necroptosis; hematopoietic or lymphoid organ development; and positive regulation of necroptotic process. Acts upstream of or within with a positive effect on non-canonical NF-kappaB signal transduction. Acts upstream of or within positive regulation of intrinsic apoptotic signaling pathway; positive regulation of protein deacetylation; and regulation of reactive oxygen species metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; immune system; male reproductive gland or organ; primitive streak; and turbinate bone primordium. Orthologous to human RIPK3 (receptor interacting serine/threonine kinase 3). PHENOTYPE: Mice homozygous for knock-out alleles exhibit resistance to induced inflammatory responses. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
