| First Author | Imura A | Year | 2007 |
| Journal | Science | Volume | 316 |
| Issue | 5831 | Pages | 1615-8 |
| PubMed ID | 17569864 | Mgi Jnum | J:122216 |
| Mgi Id | MGI:3713597 | Doi | 10.1126/science.1135901 |
| Citation | Imura A, et al. (2007) alpha-Klotho as a regulator of calcium homeostasis. Science 316(5831):1615-8 |
| abstractText | alpha-klotho was identified as a gene associated with premature aging-like phenotypes characterized by short lifespan. In mice, we found the molecular association of alpha-Klotho (alpha-Kl) and Na+,K+-adenosine triphosphatase (Na+,K+-ATPase) and provide evidence for an increase of abundance of Na+,K+-ATPase at the plasma membrane. Low concentrations of extracellular free calcium ([Ca2+]e) rapidly induce regulated parathyroid hormone (PTH) secretion in an alpha-Kl- and Na+,K+-ATPase-dependent manner. The increased Na+ gradient created by Na+,K+-ATPase activity might drive the transepithelial transport of Ca2+ in cooperation with ion channels and transporters in the choroid plexus and the kidney. Our findings reveal fundamental roles of alpha-Kl in the regulation of calcium metabolism. |
