| First Author | Cole N | Year | 2001 |
| Journal | Infect Immun | Volume | 69 |
| Issue | 6 | Pages | 4116-9 |
| PubMed ID | 11349084 | Mgi Jnum | J:69543 |
| Mgi Id | MGI:1934794 | Doi | 10.1128/IAI.69.6.4116-4119.2001 |
| Citation | Cole N, et al. (2001) Effects of Exogenous Interleukin-6 during Pseudomonas aeruginosa Corneal Infection. Infect Immun 69(6):4116-9 |
| abstractText | Lack of interleukin-6 (IL-6) during Pseudomonas aeruginosa corneal infection leads to more severe disease with changes in neutrophil recruitment. Exogenous IL-6 leads to increased efficiency of neutrophil recruitment and reduced bacterial loads in corneal infection in both IL-6 gene knockout and wild-type mice. This may be mediated by IL-6 increasing the production of corneal macrophage inflammatory protein 2 and intercellular cell adhesion molecule 1. We conclude that effective recruitment of neutrophils into the cornea is dependent on the production of IL-6 and that early augmentation of IL-6 may be protective in corneal infection. |
