| Primary Identifier | IPR025837 | Type | Domain |
| Short Name | CFTR_reg_dom |
| description | Cystic fibrosis transmembrane conductance regulator (CFTR) that belongs tothe ATP-binding cassette (ABC) transporter superfamily. It is a member of the ABC-C subfamily, which also contains the SUR receptors and the multidrug-resistance associated proteins (MRP) []. The CFTR protein encodes a chloride ion channel, which is controlled by phosphorylation. It has a majorrole in electrolyte and fluid secretion. CFTR is important in the determination of fluid flow, ion concentration and transepithelial salttransport. Dysfunction of the CFTR channel causes the life-threateningdisease, cystic fibrosis, in which trans-epithelial ion transport is disrupted []. This entry represents the CFTR regulator domain [, , ]. |
