| First Author | De Palma M | Year | 2013 |
| Journal | Cancer Cell | Volume | 24 |
| Issue | 5 | Pages | 559-61 |
| PubMed ID | 24229704 | Mgi Jnum | J:206740 |
| Mgi Id | MGI:5551928 | Doi | 10.1016/j.ccr.2013.10.019 |
| Citation | De Palma M, et al. (2013) A new twist on radiation oncology: low-dose irradiation elicits immunostimulatory macrophages that unlock barriers to tumor immunotherapy. Cancer Cell 24(5):559-61 |
| abstractText | Tumor-infiltrating macrophages typically promote angiogenesis while suppressing antitumoral T cell responses. In this issue of Cancer Cell, Klug and colleagues report that clinically-feasible, low-dose irradiation redirects macrophage differentiation from a tumor-promoting/immunosuppressive state to one that enables cytotoxic T cells to infiltrate tumors and kill cancer cells, rendering immunotherapy successful in mice. |
