| First Author | Ewbank JJ | Year | 1997 |
| Journal | Science | Volume | 275 |
| Issue | 5302 | Pages | 980-3 |
| PubMed ID | 9020081 | Mgi Jnum | J:49821 |
| Mgi Id | MGI:1278160 | Doi | 10.1126/science.275.5302.980 |
| Citation | Ewbank JJ, et al. (1997) Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1 [see comments]. Science 275(5302):980-3 |
| abstractText | Mutations in the Caenorhabditis elegans gene clk-1 affect biological timing and extend longevity. The gene clk-1 was identified, and the cloned gene complemented the clk-1 phenotypes and restored normal longevity. The CLK-1 protein was found to be conserved among eukaryotes, including humans, and structurally similar to the yeast metabolic regulator Cat5p (also called Coq7p). These proteins contain a tandem duplication of a core 82-residue domain. clk-1 complemented the phenotype of cat5/coq7 null mutants, demonstrating that clk-1 and CAT5/COQ7 share biochemical function and that clk-1 acts at the level of cellular physiology. |
