| First Author | Tomita K | Year | 1999 |
| Journal | Genes Dev | Volume | 13 |
| Issue | 9 | Pages | 1203-10 |
| PubMed ID | 10323870 | Mgi Jnum | J:55107 |
| Mgi Id | MGI:1337238 | Doi | 10.1101/gad.13.9.1203 |
| Citation | Tomita K, et al. (1999) The bHLH gene Hes1 is essential for expansion of early T cell precursors. Genes Dev 13(9):1203-10 |
| abstractText | Mice mutant for the bHLH gene Hes1, which is known to keep cells in a proliferative state, mostly lack thymus. Transfer of Hes1-null fetal liver cells into RAG2-null host mice normally reconstitutes B cells but fails to generate mature T cells in the thymus. In the reconstituted thymus, T cell differentiation is arrested at the CD4(-)CD8(-) double negative (DN) stage. Both the initial T cell receptor (TCR)-independent and the subsequent TCR-dependent selective expansion during the DN stage are severely affected. Thus, Hes1 is essential for the earliest thymocyte expansion in a cell-autonomous manner. |
