| First Author | Neppl RL | Year | 2017 |
| Journal | J Cell Biol | Volume | 216 |
| Issue | 11 | Pages | 3497-3507 |
| PubMed ID | 28855249 | Mgi Jnum | J:247276 |
| Mgi Id | MGI:5921259 | Doi | 10.1083/jcb.201612100 |
| Citation | Neppl RL, et al. (2017) lncRNA Chronos is an aging-induced inhibitor of muscle hypertrophy. J Cell Biol 216(11):3497-3507 |
| abstractText | Skeletal muscle exhibits remarkable plasticity in its ability to modulate its mass in response to the physiologic changes associated with functional use, systemic disease, and aging. Although a gradual loss of muscle mass normally occurs with advancing age, its increasingly rapid progression results in sarcopenia in a subset of individuals. The identities of muscle-enriched, long noncoding RNAs that regulate this process are unknown. Here, we identify a long noncoding RNA, named Chronos, whose expression in muscle is positively regulated with advancing age and negatively regulated during Akt1-mediated growth. Inhibition of Chronos induces myofiber hypertrophy both in vitro and in vivo, in part, through the epigenetic modulation of Bmp7 signaling. |
