| First Author | Bouffler SD | Year | 1996 |
| Journal | Radiat Res | Volume | 146 |
| Issue | 3 | Pages | 349-52 |
| PubMed ID | 8752315 | Mgi Jnum | J:35062 |
| Mgi Id | MGI:82513 | Citation | Bouffler SD, et al. (1996) Chromosomal abnormalities in neutron-induced acute myeloid leukemias in CBA/H mice. Radiat Res 146(3):349-52 |
| abstractText | Acute myeloid leukemias (AMLs) induced in CBA/H mice by 1 MeV fission neutrons have been examined for chromosomal abnormalities by G-band analysis. In common with X-ray- and alpha-particle-induced AMLs in CBA/H mice, more than 90% (16/17) of the myeloid leukemias had chromosome 2 abnormalities, in this case, all interstitial deletions, Chromosome 2 breakpoints were not wholly consistent, but clustering in three specific G-band regions was observed. Very distal (H-region) breakpoints were more common in the neutron AMLs than in X-ray- or alpha-particle-induced leukemias. These data indicate that neutron-induced AMLs in CBA/H mice are not characterized by a specific chromosome deletion but that a variety of chromosome 2 deletion types are associated with the disease. Trisomy of chromosome 1 (12.5% AMLs) and aneusomy of chromosomes 6 (31% AMLs) and Y (37.5% AMLs) were noted, While chromatid breakage was observed occasionally in neutron-induced AML, no clear indications of persistent chromosomal instability or high levels of stable chromosomal change were apparent. (C) 1996 by Radiation Research Society |
