| First Author | Murphy DB | Year | 1976 |
| Journal | J Exp Med | Volume | 144 |
| Issue | 3 | Pages | 699-712 |
| PubMed ID | 1085338 | Mgi Jnum | J:5682 |
| Mgi Id | MGI:54159 | Doi | 10.1084/jem.144.3.699 |
| Citation | Murphy DB, et al. (1976) A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes. J Exp Med 144(3):699-712 |
| abstractText | In an accompanying publication we show that a subpopulation of T lymphocytes, which includes allotype suppressor T cells, selectively expresses I-region determinants. In this report, we show that these determinants are controlled by a new locus, Ia-4. Unlike the classically defined Ia antigens, they are not found on B lymphocytes. Antibody against Ia-4 determinants cannot be detected by conventional dye exclusion cytoxicity assays, suggesting that they are present on a small subpopulation (less than 10%) of peripheral T lymphocytes. The Ia-4 locus marks a new I subregion, provisionally designated I-J. This chromosomal segment is defined by the crossover positions in strains B10.A(5R) (K-end boundary) and B10.HTT (D-end boundary), and maps between the I-B and I-C subregions. |
