| First Author | Jeon D | Year | 2003 |
| Journal | Neuron | Volume | 38 |
| Issue | 6 | Pages | 965-76 |
| PubMed ID | 12818181 | Mgi Jnum | J:84050 |
| Mgi Id | MGI:2664655 | Doi | 10.1016/s0896-6273(03)00334-9 |
| Citation | Jeon D, et al. (2003) Enhanced learning and memory in mice lacking Na+/Ca2+ exchanger 2. Neuron 38(6):965-76 |
| abstractText | The plasma membrane Na(+)/Ca(2+) exchanger (NCX) plays a role in regulation of intracellular Ca(2+) concentration via the forward mode (Ca(2+) efflux) or the reverse mode (Ca(2+) influx). To define the physiological function of the exchanger in vivo, we generated mice deficient for NCX2, the major isoform in the brain. Mutant hippocampal neurons exhibited a significantly delayed clearance of elevated Ca(2+) following depolarization. The frequency threshold for LTP and LTD in the hippocampal CA1 region was shifted to a lowered frequency in the mutant mice, thereby favoring LTP. Behaviorally, the mutant mice exhibited enhanced performance in several hippocampus-dependent learning and memory tasks. These results demonstrate that NCX2 can be a temporal regulator of Ca(2+) homeostasis and as such is essential for the control of synaptic plasticity and cognition. |
