| First Author | Xie C | Year | 2016 |
| Journal | J Neuroimmunol | Volume | 291 |
| Pages | 59-69 | PubMed ID | 26857496 |
| Mgi Jnum | J:329766 | Mgi Id | MGI:6851658 |
| Doi | 10.1016/j.jneuroim.2015.12.009 | Citation | Xie C, et al. (2016) IL-12Rbeta2 has a protective role in relapsing-remitting experimental autoimmune encephalomyelitis. J Neuroimmunol 291:59-69 |
| abstractText | IL-12Rbeta2 is a common receptor subunit of heterodimeric receptors for IL-12 and IL-35, two cytokines that are implicated in immunopathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. We evaluated the role of IL-12Rbeta2 in relapsing-remitting EAE (RR-EAE). IL-12Rbeta2-deficient SJL/J mice developed markedly more severe clinical EAE, and had greater mortality and more severe relapses compared with wild-type controls. IL-12Rbeta2-deficient EAE mice also had more infiltrating mononuclear cells in the CNS, as well as higher T cell proliferative capacity and decreased IFN-gamma production at the periphery. These findings demonstrate a protective role of IL-12Rbeta2 in RR-EAE. |
