| Primary Identifier | MGI:1349766 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 26992 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables transcription corepressor activity. Predicted to be involved in negative regulation of G1/S transition of mitotic cell cycle and regulation of gene expression. Predicted to act upstream of or within Wnt signaling pathway. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; lung; retina; and tooth. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human BRD7 (bromodomain containing 7). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired cognitive behavior and dendrite morphology in the medial prefrontal cortex as well as male infertility with azoospermia and globozoospermia. Mice homozygous for a different knock-out allele die in utero prior to E16.5, showing fetal growth retardation and altered limb, blood vessel and organ development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
