mice infected with MERS-CoV exhibit weight loss, hypothermia, and die at 6-7 days post infection (dpi) viral titers are highest in lung tissues at 2dpi and then decline while in the brain, viral titers are undetectable at 2 dpi but then increase at 4 and 6 dpi virus RNA is detected in the lung and brain and lower levels in the spleen, kidney and heart even though no virus was titered from the kidney MERS-CoV is not transmitted from infected transgenic mice to uninfected transgenic mice housed in the same cages
