| Primary Identifier | MGI:893578 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 20778 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables amyloid-beta binding activity; apolipoprotein binding activity; and high-density lipoprotein particle binding activity. Involved in several processes, including cholesterol homeostasis; lipid transport; and regulation of lipid metabolic process. Acts upstream of or within several processes, including blood vessel endothelial cell migration; cholesterol catabolic process; and intestinal lipid absorption. Located in caveola; cell surface; and cytoplasm. Is expressed in several structures, including alimentary system; brain; early conceptus; hemolymphoid system gland; and reproductive system. Orthologous to human SCARB1 (scavenger receptor class B member 1). PHENOTYPE: Targeted mutations result in abnormal lipoprotein metablolism and, for one allele, reversible female infertility. An ENU mutant shows increased cholesterol levels. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
