| Primary Identifier | MGI:97361 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 18126 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables several functions, including anion binding activity; heme binding activity; and nitric-oxide synthase activity. Involved in several processes, including negative regulation of macromolecule metabolic process; nitric oxide biosynthetic process; and response to lipopolysaccharide. Acts upstream of or within several processes, including cellular response to type II interferon; response to bacterium; and superoxide metabolic process. Located in cortical cytoskeleton and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; enteric nervous system; genitourinary system; and hemolymphoid system gland. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); hypertension (multiple); malaria; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human NOS2 (nitric oxide synthase 2). PHENOTYPE: Homozygous deletion of this gene alters susceptibility to infection, response to injury, sepsis and sensory stimuli, cardiac function, osteoclast, platelet and mammary gland physiology, tumor growth, testis and uterus morphology, diet-induced atherosclerosis, and blood, urine and glucose metabolism. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
