| Primary Identifier | MGI:1919420 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 72170 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable protein-disulfide reductase activity. Involved in mitochondrial respiratory chain complex assembly. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; mitochondrial DNA repair; and regulation of protein export from nucleus. Located in mitochondrion. Is expressed in brain; embryo; liver; and spleen. Orthologous to human CHCHD4 (coiled-coil-helix-coiled-coil-helix domain containing 4). PHENOTYPE: Embryos homozygous for a knock-out allele exhibit respiratory electron transport chain defects, growth retardation, and complete embryonic lethality. Heterozygotes are viable and overtly normal but show decreased susceptibility to diet-induced obesity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
