Primary Identifier | IPR037561 | Type | Family |
Short Name | Complement_factor_D |
description | This entry represents complement factor D (known as serine protease ami in Xenopus species; MEROPS identifier S01.191), a serine endopeptidase from the S1 (chymotrypsin) family. The only known physiological substrate of factor D is complement factor B, hydrolysing a single Arg-Lys bond when factor B is in complex with complement factor 3b []. Factor D is synthesized as an inactive precursor which is activated intracellularly before it is secreted []. Factor D has the lowest concentration of any complement component in the blood, and its activity is the rate limiting step in complement activation in the alternative pathway []. |