| First Author | Hamvas RM | Year | 1992 |
| Journal | Genomics | Volume | 12 |
| Issue | 2 | Pages | 363-7 |
| PubMed ID | 1740345 | Mgi Jnum | J:2950 |
| Mgi Id | MGI:51466 | Doi | 10.1016/0888-7543(92)90386-7 |
| Citation | Hamvas RM, et al. (1992) Rps4 maps near the inactivation center on the mouse X chromosome. Genomics 12(2):363-7 |
| abstractText | RPS4Y, a Y-linked gene in humans, appears to encode an isoform of ribosomal protein S4. A homologous locus on the human X chromosome, RPS4X, lies close to the X-inactivation center but fails to undergo X-inactivation. We have isolated a genomic clone from the mouse Rps4 locus, the homolog of human RPS4X. We derived an intron probe that hybridizes to the functional Rps4 locus but does not cross-hybridize to related sequences elsewhere in the mouse genome. Genetic mapping utilizing interspecific mouse backcrosses and the intron-specific probe demonstrates that Rps4 maps close to the Phka locus on the mouse X chromosome and in the vicinity of the X-inactivation center. The gene order Ccg-1-Rps4/Phka-Xist-Pgk-1 is conserved between mouse and human. |
