| First Author | Arthur DB | Year | 2006 |
| Journal | Biochem Biophys Res Commun | Volume | 347 |
| Issue | 3 | Pages | 678-82 |
| PubMed ID | 16842754 | Mgi Jnum | J:111267 |
| Mgi Id | MGI:3653538 | Doi | 10.1016/j.bbrc.2006.06.141 |
| Citation | Arthur DB, et al. (2006) P2Y2 and TrkA receptors interact with Src family kinase for neuronal differentiation. Biochem Biophys Res Commun 347(3):678-82 |
| abstractText | The crosstalk between the P2Y(2) G-protein-coupled receptor (GPCR) with TrkA receptor tyrosine kinase (RTK) is an important mechanism that regulates neuronal differentiation. We show that Src family kinases (SFK) regulate P2Y(2)-TrkA molecular crosstalk. SFK inhibitors block ATPgammaS/P2Y(2)-promoted enhancement of NGF/TrkA signaling and neuronal differentiation in PC12 cells, abrogate the enhancement by ATPgammaS of neurite outgrowth in primary cultures of dorsal root ganglion neurons, and block co-immunoprecipitation of TrkA, P2Y(2) receptors and SFK. These results identify SFK as mediating nucleotide-enhanced neurotrophin-dependent neuronal differentiation and thus, as a key convergence point for interaction between RTKs and GPCRs. |
