| Primary Identifier | MGI:104616 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 12771 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables C-C chemokine binding activity and C-C chemokine receptor activity. Involved in positive regulation of angiogenesis and positive regulation of endothelial cell proliferation. Acts upstream of or within chemokine-mediated signaling pathway and chemotaxis. Predicted to be located in endosome; extracellular space; and plasma membrane. Predicted to be active in cytoplasm and external side of plasma membrane. Is expressed in embryo and yolk sac. Human ortholog(s) of this gene implicated in asthma; ovary epithelial cancer; and rhinitis. Orthologous to human CCR3 (C-C motif chemokine receptor 3). PHENOTYPE: Homozygous mutation of this gene results in impaired eosinophil trafficking to the lungs and small intestine, and in increased bronchorestriction following methacholine challenge. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
