| First Author | Frelin C | Year | 2013 |
| Journal | Nat Immunol | Volume | 14 |
| Issue | 10 | Pages | 1037-44 |
| PubMed ID | 23974957 | Mgi Jnum | J:208223 |
| Mgi Id | MGI:5562499 | Doi | 10.1038/ni.2692 |
| Citation | Frelin C, et al. (2013) GATA-3 regulates the self-renewal of long-term hematopoietic stem cells. Nat Immunol 14(10):1037-44 |
| abstractText | The transcription factor GATA-3 is expressed and required for differentiation and function throughout the T lymphocyte lineage. Despite evidence it may also be expressed in multipotent hematopoietic stem cells (HSCs), any role for GATA-3 in these cells has remained unclear. Here we found GATA-3 was in the cytoplasm in quiescent long-term stem cells from steady-state bone marrow but relocated to the nucleus when HSCs cycled. Relocation depended on signaling via the mitogen-activated protein kinase p38 and was associated with a diminished capacity for long-term reconstitution after transfer into irradiated mice. Deletion of Gata3 enhanced the repopulating capacity and augmented the self-renewal of long-term HSCs in cell-autonomous fashion without affecting the cell cycle. Our observations position GATA-3 as a regulator of the balance between self-renewal and differentiation in HSCs that acts downstream of the p38 signaling pathway. |
