| Primary Identifier | MGI:1196391 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 18973 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable DNA binding activity; catalytic activity, acting on DNA; and chromatin binding activity. Predicted to be involved in DNA metabolic process and G1/S transition of mitotic cell cycle. Predicted to act upstream of or within DNA repair. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of epsilon DNA polymerase complex. Is expressed in nervous system. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); endometrial cancer (multiple); lung cancer (multiple); and mismatch repair cancer syndrome. Orthologous to human POLE (DNA polymerase epsilon, catalytic subunit). PHENOTYPE: Mice homozygous for a knock-in allele exhibit increased incidence of tumors and premature death. Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E7. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
