| First Author | Ebihara S | Year | 1988 |
| Journal | Brain Res | Volume | 454 |
| Issue | 1-2 | Pages | 404-7 |
| PubMed ID | 3409025 | Mgi Jnum | J:27107 |
| Mgi Id | MGI:74525 | Doi | 10.1016/0006-8993(88)90847-5 |
| Citation | Ebihara S, et al. (1988) The phase-shifting effects of pentobarbital on the circadian rhythm of locomotor activity in the mouse: strain differences. Brain Res 454(1-2):404-7 |
| abstractText | The phase response curves (PRCs) generated by pentobarbital injections (30 mg/kg) were obtained in SK and C57BL mice. Pentobarbital injections induced both advance and delay phase-shifts in the circadian rhythm of locomotor activity in SK mice but no phase-shifts were observed at any circadian time (CT) for pentobarbital injections in C57BL mice. The observation that a higher dose of pentobarbital (80 mg/kg) does not induce phase-shifting in C57BL mice has indicated that the differences in phase-shifting effects of pentobarbital are not quantitative but qualitative. These strains may be useful for studying the neurochemical regulation of the mammalian circadian rhythm. |
