| Primary Identifier | MGI:5049781 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Lepr |
| Transmission | Germline | Strain of Origin | 129P3/J |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 4 was replaced with a modified exon 4 in which nucleotide substitutions (CAG to CGA) result in the amino acid substitution of arginine for glutamine at position 223 (Q223R). This mutation humanizes the protein. An floxed neo cassette inserted downstream of the modified exon was removed by cre-mediated recombination. |
