First Author | Skwarek LC | Year | 2009 |
Journal | Dev Cell | Volume | 16 |
Issue | 1 | Pages | 12-20 |
PubMed ID | 19154715 | Mgi Jnum | J:144984 |
Mgi Id | MGI:3833044 | Doi | 10.1016/j.devcel.2008.12.006 |
Citation | Skwarek LC, et al. (2009) Great expectations for PIP: phosphoinositides as regulators of signaling during development and disease. Dev Cell 16(1):12-20 |
abstractText | Phosphoinositides function as signaling precursors as well as regulators and scaffolds of signaling molecules required for important cellular processes such as membrane trafficking. Although a picture of the biochemical and cell biological functions of phosphoinositides is emerging, less is known about how these functions impact signaling on a broader scale during development. This review summarizes recent work on the role of phosphoinositides in developmental signaling and in a number of diseases and developmental disorders. |