| First Author | Leinweber M | Year | 2017 |
| Journal | Neuron | Volume | 95 |
| Issue | 6 | Pages | 1420-1432.e5 |
| PubMed ID | 28910624 | Mgi Jnum | J:253236 |
| Mgi Id | MGI:6109156 | Doi | 10.1016/j.neuron.2017.08.036 |
| Citation | Leinweber M, et al. (2017) A Sensorimotor Circuit in Mouse Cortex for Visual Flow Predictions. Neuron 95(6):1420-1432.e5 |
| abstractText | The cortex is organized as a hierarchical processing structure. Feedback from higher levels of the hierarchy, known as top-down signals, have been shown to be involved in attentional and contextual modulation of sensory responses. Here we argue that top-down input to the primary visual cortex (V1) from A24b and the adjacent secondary motor cortex (M2) signals a prediction of visual flow based on motor output. A24b/M2 sends a dense and topographically organized projection to V1 that targets most neurons in layer 2/3. By imaging the activity of A24b/M2 axons in V1 of mice learning to navigate a 2D virtual environment, we found that their activity was strongly correlated with locomotion and resulting visual flow feedback in an experience-dependent manner. When mice were trained to navigate a left-right inverted virtual environment, correlations of neural activity with behavior reversed to match visual flow. These findings are consistent with a predictive coding interpretation of visual processing. |
