| Primary Identifier | IPR026577 | Type | Domain |
| Short Name | SeqA_DNA-bd_C |
| description | The binding of the negative modulator of initiation of replication (SeqA) protein to hemimethylated GATC sequences is important in the negative modulation of chromosomal initiation at oriC, and in the formation of SeqA foci necessary for Escherichia coli chromosome segregation []. SeqA tetramers are able to aggregate or multimerize in a reversible, concentration-dependent manner []. Apart from its function in the control of DNA replication, SeqA may also be a specific transcription factor [].The C-terminal domain binds DNA, binding to hemimethylated GATC sequences at oriC [, ]. The structure of the C-terminal domain consists of seven α-helices and three-stranded β-sheet. |
