| First Author | Shefer VI | Year | 1998 |
| Journal | Exp Gerontol | Volume | 33 |
| Issue | 5 | Pages | 467-76 |
| PubMed ID | 9762524 | Mgi Jnum | J:48921 |
| Mgi Id | MGI:1276213 | Doi | 10.1016/s0531-5565(98)00009-6 |
| Citation | Shefer VI, et al. (1998) The effect of exercise training in cold on shivering and nonshivering thermogenesis in adult and aged C57BL/6J mice. Exp Gerontol 33(5):467-76 |
| abstractText | To understand the mechanisms of improvement of cold-induced heat production in aged mice following exercise training, the relative contributions of shivering and nonshivering thermogenesis to cold-induced metabolic responses were assessed in adult and aged C57BL/6J male mice, which inhabited sedentarily at room temperature, or were subjected either to a regimen of moderate intensity exercise training at 6 degrees C, or to sedentary repeated exposures to the same temperature. The main findings were that (1) aged mice had greater cold-induced nonshivering thermogenesis, but lower shivering than adult mice; (2) exercise training in a cold environment enhanced cold-induced nonshivering thermogenesis in adult mice, but suppressed it in aged animals; (3) exercise training in a cold environment increased shivering thermogenesis in both age groups, but this increase was much greater in aged mice; (4) the increase of cold-induced shivering thermogenesis was mainly responsible for increased cold tolerance in aged mice after exercise training in a cold environment. |
