| First Author | Roark JH | Year | 1995 |
| Journal | J Immunol | Volume | 154 |
| Issue | 9 | Pages | 4444-55 |
| PubMed ID | 7722301 | Mgi Jnum | J:24962 |
| Mgi Id | MGI:72677 | Doi | 10.4049/jimmunol.154.9.4444 |
| Citation | Roark JH, et al. (1995) B cell selection and allelic exclusion of an anti-DNA Ig transgene in MRL-lpr/lpr mice. J Immunol 154(9):4444-55 |
| abstractText | We have used an Ig transgene (VH3H9) that increases the frequency of anti-DNA autoantibodies to address whether the production of antinuclear Abs in systemic lupus erythematosus is the consequence of a breakdown of B cell tolerance. We have shown that nonautoimmune mice regulate anti-DNA B cells, and that lupus-prone MRL-lpr/lpr mice are defective in this regulation. Here we show that a subset of anti-DNA B cells, namely those that stain nuclei in a homogeneous fashion, not only fail to be deleted in MRL-lpr/lpr mice, but undergo preferential clonal expansion. In addition, we describe a surprising finding: the VH3H9 transgene is less efficient at inhibiting endogenous heavy chain gene rearrangement on the autoimmune-prone MRL-lpr/lpr genetic background than on the nonautoimmune BALB/c background. |
