| First Author | McIntire JJ | Year | 2001 |
| Journal | Nat Immunol | Volume | 2 |
| Issue | 12 | Pages | 1109-16 |
| PubMed ID | 11725301 | Mgi Jnum | J:72894 |
| Mgi Id | MGI:2153947 | Doi | 10.1038/ni739 |
| Citation | McIntire JJ, et al. (2001) Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat Immunol 2(12):1109-16 |
| abstractText | To simplify the analysis of asthma susceptibility genes located at human chromosome 5q23-35, we examined congenic mice that differed at the homologous chromosomal segment. We identified a Mendelian trait encoded by T cell and Airway Phenotype Regulator (Tapr). Tapr is genetically distinct from known cytokine genes and controls the development of airway hyperreactivity and T cell production of interleukin 4 (IL-4) and IL-13. Positional cloning identified a gene family that encodes T cell membrane proteins (TIMs); major sequence variants of this gene family (Tim) completely cosegregated with Tapr. The human homolog of TIM-1 is the hepatitis A virus (HAV) receptor, which may explain the inverse relationship between HAV infection and the development of atopy. |
