| First Author | Leist SR | Year | 2020 |
| Journal | Dis Model Mech | Volume | 13 |
| Issue | 9 | PubMed ID | 32887790 |
| Mgi Jnum | J:295328 | Mgi Id | MGI:6456966 |
| Doi | 10.1242/dmm.046581 | Citation | Leist SR, et al. (2020) Cell and animal models of SARS-CoV-2 pathogenesis and immunity. Dis Model Mech 13(9):dmm046581 |
| abstractText | The spread of the novel virus SARS coronavirus 2 (SARS-CoV-2) was explosive, with cases first identified in December 2019, and >22 million people infected and >775,000 deaths as of August 2020. SARS-CoV-2 can cause severe respiratory disease in humans leading to coronavirus disease 2019 (COVID-19). The development of effective clinical interventions, such as antivirals and vaccines that can limit or even prevent the burden and spread of SARS-CoV-2, is a global health priority. Testing of leading antivirals, monoclonal antibody therapies and vaccines against SARS-CoV-2 will require robust animal and cell models of viral pathogenesis. In this Special Article, we discuss the cell-based and animal models of SARS-CoV-2 infection and pathogenesis that have been described as of August 2020. We also outline the outstanding questions for which researchers can leverage animal and cell-based models to improve our understanding of SARS-CoV-2 pathogenesis and protective immunity. Taken together, the refinement of models of SARS-CoV-2 infection will be critical to guide the development of therapeutics and vaccines against SARS-CoV-2 to end the COVID-19 pandemic. |
