| First Author | Szalai AJ | Year | 2014 |
| Journal | Trans R Soc Trop Med Hyg | Volume | 108 |
| Issue | 9 | Pages | 591-3 |
| PubMed ID | 25002461 | Mgi Jnum | J:327640 |
| Mgi Id | MGI:7333249 | Doi | 10.1093/trstmh/tru098 |
| Citation | Szalai AJ, et al. (2014) Deletion of C-reactive protein ameliorates experimental cerebral malaria?. Trans R Soc Trop Med Hyg 108(9):591-3 |
| abstractText | BACKGROUND: C-reactive protein (CRP) level correlates with parasitemia and severity of malaria, but whether this reflects causality remains unknown. METHODS: Using CRP-transgenic and CRP-deficient mice we compared the onset and severity of experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA (PbA). RESULTS: CRP-deficient mice were most resistant to ECM. CONCLUSIONS: CRP might contribute to the development of cerebral malaria, rather than protect against it. |
