| First Author | Barberà-Cremades M | Year | 2012 |
| Journal | FASEB J | Volume | 26 |
| Issue | 7 | Pages | 2951-62 |
| PubMed ID | 22490780 | Mgi Jnum | J:328403 |
| Mgi Id | MGI:6868038 | Doi | 10.1096/fj.12-205765 |
| Citation | Barbera-Cremades M, et al. (2012) P2X7 receptor-stimulation causes fever via PGE2 and IL-1beta release. FASEB J 26(7):2951-62 |
| abstractText | Prostaglandins (PGs) are important lipid mediators involved in the development of inflammatory associated pain and fever. PGE2 is a well-established endogenous pyrogen activated by proinflammatory cytokine interleukin (IL)-1beta. P2X7 receptors (P2X7Rs) expressed by inflammatory cells are stimulated by the danger signal extracellular ATP to activate the inflammasome and release IL-1beta. Here we show that P2X7R activation is required for the release of PGE2 and other autacoids independent of inflammasome activation, with an ATP EC(50) for PGE2 and IL-1beta release of 1.58 and 1.23 mM, respectively. Furthermore, lack of P2X7R or specific antagonism of P2X7R decreased the febrile response in mice triggered after intraperitoneal LPS or IL-1beta inoculation. Accordingly, LPS inoculation caused intraperitoneal ATP accumulation. Therefore, P2X7R antagonists emerge as novel therapeutics for the treatment for acute inflammation, pain and fever, with wider anti-inflammatory activity than currently used cyclooxygenase inhibitors.-Barbera-Cremades, M., Baroja-Mazo, A., Gomez, A. I., Machado, F., Di Virgilio, F., Pelegrin, P. P2X7 receptor-stimulation causes fever via PGE2 and IL-1beta release. |
