| First Author | Lee DS | Year | 1999 |
| Journal | Immunity | Volume | 10 |
| Issue | 1 | Pages | 83-92 |
| PubMed ID | 10023773 | Mgi Jnum | J:110458 |
| Mgi Id | MGI:3640252 | Doi | 10.1016/s1074-7613(00)80009-6 |
| Citation | Lee DS, et al. (1999) Thymic selection by a single MHC/peptide ligand: autoreactive T cells are low-affinity cells. Immunity 10(1):83-92 |
| abstractText | In H2-M- mice, the presence of a single peptide, CLIP, bound to MHC class II molecules generates a diverse repertoire of CD4+ cells. In these mice, typical self-peptides are not bound to class II molecules, with the result that a very high proportion of H2-M- CD4+ cells are responsive to the various peptides displayed on normal MHC-compatible APC. We show here, however, that such 'self' reactivity is controlled by low-affinity CD4+ cells. These cells give spectacularly high proliferative responses but are virtually unreactive in certain other assays, e.g., skin graft rejection; responses to MHC alloantigens, by contrast, are intense in all assays. Possible explanations for why thymic selection directed to a single peptide curtails self specificity without affecting alloreactivity are discussed. |
