| First Author | Zenz R | Year | 2003 |
| Journal | Dev Cell | Volume | 4 |
| Issue | 6 | Pages | 879-89 |
| PubMed ID | 12791272 | Mgi Jnum | J:84512 |
| Mgi Id | MGI:2668003 | Doi | 10.1016/s1534-5807(03)00161-8 |
| Citation | Zenz R, et al. (2003) c-Jun Regulates Eyelid Closure and Skin Tumor Development through EGFR Signaling. Dev Cell 4(6):879-89 |
| abstractText | To investigate the function of c-Jun during skin development and skin tumor formation, we conditionally inactivated c-jun in the epidermis. Mice lacking c-jun in keratinocytes (c-jun(Deltaep)) develop normal skin but express reduced levels of EGFR in the eyelids, leading to open eyes at birth, as observed in EGFR null mice. Primary keratinocytes from c-jun(Deltaep) mice proliferate poorly, show increased differentiation, and form prominent cortical actin bundles, most likely because of decreased expression of EGFR and its ligand HB-EGF. In the absence of c-Jun, tumor-prone K5-SOS-F transgenic mice develop smaller papillomas, with reduced expression of EGFR in basal keratinocytes. Thus, using three experimental systems, we show that EGFR and HB-EGF are regulated by c-Jun, which controls eyelid development, keratinocyte proliferation, and skin tumor formation. |
