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Protein Coding Gene : Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6

Primary Identifier  MGI:104781 Organism  mouse, laboratory
Chromosome  16 NCBI Gene Number  16522
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables G-protein activated inward rectifier potassium channel activity and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Acts upstream of or within monoatomic ion transmembrane transport; regulation of presynaptic membrane potential; and thyroid hormone metabolic process. Is active in parallel fiber to Purkinje cell synapse; postsynapse; and presynaptic membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in alcohol use disorder and heroin dependence. Orthologous to human KCNJ6 (potassium inwardly rectifying channel subfamily J member 6).
PHENOTYPE: A spontaneous mutation exhibits small size, ataxia, hypotonia, high periweaning mortality, Purkinje cell defects, and male sterility. Homozygotes for a targeted null mutation exhibit increased susceptibility to spontaneous and drug-induced seizures. [provided by MGI curators]
  • synonyms:
  • wv,
  • MGD-MRK-28073,
  • MGD-MRK-15467,
  • potassium inwardly-rectifying channel, subfamily J, member 6,
  • Kir3.2,
  • weaver,
  • GIRK2,
  • Kcnj6,
  • KCNJ7

Features --> Cross References

Genome

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

11 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

11 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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0 Driver For