| First Author | Yeh JH | Year | 2008 |
| Journal | Cell | Volume | 132 |
| Issue | 5 | Pages | 846-59 |
| PubMed ID | 18329370 | Mgi Jnum | J:145314 |
| Mgi Id | MGI:3834299 | Doi | 10.1016/j.cell.2008.01.013 |
| Citation | Yeh JH, et al. (2008) Regulation of a late phase of T cell polarity and effector functions by Crtam. Cell 132(5):846-59 |
| abstractText | Spatial organization of cellular proteins plays an important role in establishment of cellular polarity to regulate cell division, differentiation, migration, and organogenesis. Activation of T cells by antigen-presenting cells (APCs) results in the formation of an immunological synapse (IS), assembly of a signaling scaffold at the T cell receptor (TCR) contact, cytoskeletal reorganization, and generation of second messengers within the first hours following intercellular contact. We demonstrate here that Crtam (class-I MHC-restricted T-cell associated molecule), an immunoglobulin-superfamily transmembrane protein, coordinates a signaling complex anchored by the Scrib polarity protein to establish a later phase of T cell polarity on a subset of CD4+ T cells >6 hours following activation. Maintenance of this late cellular polarity results in the ability of CD4+Crtam+ T cells to selectively produce more IFNgamma and IL22. Crtam engagement thus modulates signals many hours beyond the initial activation event and dynamically influences the adaptive immune response. |
