| First Author | Ludwig T | Year | 2001 |
| Journal | Genes Dev | Volume | 15 |
| Issue | 10 | Pages | 1188-93 |
| PubMed ID | 11358863 | Mgi Jnum | J:69187 |
| Mgi Id | MGI:1934275 | Doi | 10.1101/gad.879201 |
| Citation | Ludwig T, et al. (2001) Tumorigenesis in mice carrying a truncating Brca1 mutation. Genes Dev 15(10):1188-93 |
| abstractText | We generated mouse mutants carrying in the Brca1 locus a modification (Brca1(tr)) that eliminates the C-terminal half of the protein product and obtained results indicating that, depending on genetic background, the missing BRCT and/or other domains are dispensable for survival, but essential for tumor suppression. Most of the apparently hypomorphic Brca1(tr/tr) mutants developed various tumors. Lymphomas were detected at all ages, whereas sarcomas and carcinomas, including breast cancer, appeared after a long latency. The mammary tumors showed striking variability in histopathological patterns suggesting stochastic engagement of tumorigenic pathways in their progression, to which the Brca1(tr/tr) mutation was apparently a late participant. |
