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Protein Coding Gene : Capza3 capping actin protein of muscle Z-line subunit alpha 3
Primary Identifier  MGI:106221 Organism  mouse, laboratory
Chromosome  6 NCBI Gene Number  12344
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization and barbed-end actin filament capping. Predicted to act upstream of or within actin filament capping. Located in cortical cytoskeleton and membrane. Orthologous to human CAPZA3 (capping actin protein of muscle Z-line subunit alpha 3).
PHENOTYPE: Males homozygous for an ENU-induced mutation are infertile, exhibit low epididymal sperm concentrations, and produce sperm with abnormally shaped heads and poor motility. [provided by MGI curators]
  • synonyms:
  • cp alpha3,
  • Cappa3,
  • Gsg3,
  • capping protein alpha 3,
  • capping actin protein of muscle Z-line subunit alpha 3,
  • testis expressed gene 8,
  • 510-4,
  • MGD-MRK-23797,
  • MGD-MRK-33913,
  • MGI:3590184,
  • repro32,
  • reproductive mutant 32, JAX Reproductive Mutagenesis Program,
  • Capza3,
  • Tex8
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