| First Author | Ferradini L | Year | 1996 |
| Journal | Science | Volume | 271 |
| Issue | 5254 | Pages | 1416-20 |
| PubMed ID | 8596914 | Mgi Jnum | J:31727 |
| Mgi Id | MGI:79214 | Doi | 10.1126/science.271.5254.1416 |
| Citation | Ferradini L, et al. (1996) Rearrangement-enhancing element upstream of the mouse immunoglobulin kappa chain J cluster. Science 271(5254):1416-20 |
| abstractText | Transcriptional regulatory elements have been shown to be necessary but not sufficient for the developmental regulation of immunoglobulin gene rearrangement in mouse precursor B cells. In the chicken lambda light chain locus, additional elements in the V-J intervening sequence are involved in negative and positive regulation of rearrangement. Here, mutation of the mouse homolog of a chicken element, located in the V-kappa-J(kappa) intervening sequence upstream of the J(kappa) duster, was shown to significantly decrease rearrangement. This cis- acting recombination-enhancing element affects the rearrangement process without being involved in regulating transcription. |
