| First Author | Fredrickson TN | Year | 1999 |
| Journal | Am J Pathol | Volume | 154 |
| Issue | 3 | Pages | 805-12 |
| PubMed ID | 10079258 | Mgi Jnum | J:53351 |
| Mgi Id | MGI:1332333 | Doi | 10.1016/S0002-9440(10)65327-8 |
| Citation | Fredrickson TN, et al. (1999) Splenic marginal zone lymphomas of mice. Am J Pathol 154(3):805-12 |
| abstractText | Splenic marginal zone lymphomas (MZLs) have been found to occur at a high frequency in NFS.N mice congenic for high- expressing ecotropic murine leukemia virus (MuLV) genes from AKR and C58 mice. Based on morphological, immunological, and molecular studies of these mice, MZL is clearly recognizable as a distinct disease with a characteristic clinical behavior. MZL was staged according to the degree of accumulation and morphological change of cells within the splenic marginal zone, as follows: 1) a moderate Increase in normal-looking MZ cells,judged to be prelymphomatous, and 2) MZL in three variants: i) distinct enlargement of MZ by normal-looking cells (MZL), ii) distinct enlargement of MZ by basophilic centroblast-like cells (MZL+), and iii) extensive splenic involvement by centroblast-like cells (MZL++). The rate of mitosis and apoptosis increases with lymphoma grade. In most cases, emergence of a dominant IgH clonal pattern in paired splenic biopsy and necropsy samples was correlated with progression. MZLs were transplantable and homed to the spleen. MZL may constitute a commonly occurring lymphoma type unrecognized, in part, because of the centroblastic morphology of high-grade MZL and possible overgrowth of lower-grade MZL by more aggressive follicular lymphomas. |
