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Publication : The homeodomain LIM protein Isl-1 is expressed in subsets of neurons and endocrine cells in the adult rat.

First Author  Thor S Year  1991
Journal  Neuron Volume  7
Issue  6 Pages  881-9
PubMed ID  1764243 Mgi Jnum  J:32883
Mgi Id  MGI:80369 Doi  10.1016/0896-6273(91)90334-v
Citation  Thor S, et al. (1991) The homeodomain LIM protein Isl-1 is expressed in subsets of neurons and endocrine cells in the adult rat. Neuron 7(6):881-9
abstractText  We have used immunocytochemical methods to localize the homeodomain LIM protein Isl-1 in the adult rat. Isl-1 immunoreactivity is expressed in polypeptide hormone-producing cells of the endocrine system, in neurons of the peripheral nervous system, and in a subset of brain nuclei. Isl-1 is also expressed in a subset of motoneurons in the spinal cord and brain stem, but not in regions of the central nervous system involved in sensory function or in neocortical areas. The pattern of expression of Isl-1 suggests that this gene may be involved in the specification and maintenance of differentiated phenotypical properties of these cells.
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