| First Author | Greenfield A | Year | 1996 |
| Journal | Nat Genet | Volume | 14 |
| Issue | 4 | Pages | 474-8 |
| PubMed ID | 8944031 | Mgi Jnum | J:36994 |
| Mgi Id | MGI:84400 | Doi | 10.1038/ng1296-474 |
| Citation | Greenfield A, et al. (1996) An H-YDb epitope is encoded by a novel mouse Y chromosome gene. Nat Genet 14(4):474-8 |
| abstractText | Rejection of male tissue grafts by genotypically identical female mice has been explained by the existence of a male- specific transplantation antigen, H-Y (ref. 1), but the molecular nature of H-Y antigen has remained obscure. Hya, the murine locus controlling H-Y expression, has been localized to Delta Sxr(b), a deletion interval of the short arm of the Y chromosome(2). In mice, H-Y antigen comprises at least four distinct epitopes, each recognized by a specific T lymphocyte clone. It has recently been shown that one of these epitopes, H-YKk, is a peptide encoded by the Y-linked Smcy gene, presented at the cell surface with the H-2K(k) major histocompatibility complex (MHC) molecule(3). However, deletion mapping and the analysis of variable inactivation of H-Y epitopes has suggested that the Hya locus may be genetically complex(4,5). Here we describe a novel mouse Y chromosome gene which we call Uty (ubiquitously transcribed tetratricopeptide repeat gene on the Y chromosome). We identify the peptide WMHHNMDLI derived from the UTY protein as an H-Y epitope, H-YDb. Our data formally demonstrate that H-Y antigen is the product of more than one gene on the Y chromosome. |
